Generic Name: Tranexamic Acid 500/5mg/ml
Company Name: Renata Pharma Ltd
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Indications
Bleeding is treated with Xamic IV/IM. In situations like tooth extraction, heavy periods, dysfunctional uterine bleeding, nosebleeds, as well as any oral, prostate, or bladder surgery, it helps to either avoid or lessen bleeding. A fibrinolytic agent is Xamic IV/IM. It stops bleeding by preventing the disintegration of blood clots. The doctor's recommended dose and duration for taking this medication must be followed.
Pharmacology
This is a preparation of tranexamic acid (trans-4-amino methylcyclohexane carboxylic acid). According to the test, Tranexamic acid is a substance with a strong anti-fibrinolytic effect. In vivo and in vitro, its activity is 10 times that of traditional hemostatic agents. The anti-bleeding effect of tranexamic acid is mainly due to the inhibition of plasminogen activation by exogenous activators (such as streptokinase) and endogenous activators (such as urokinase and tissue plasminogen activators). This fact is particularly important for the clinical application of tranexamic acid because it ensures anti-hemorrhage activity against fibrinolytic mechanisms under various conditions.
Tranexamic acid has very low acute toxicity and almost no chronic toxicity. Tranexamic acid is well absorbed orally, and the effect can be observed 1530 minutes after administration. It is mainly excreted through the kidneys, but more slowly than traditional hemostatic agents. These characteristics make the effect of tranexamic acid longer than traditional hemostatic agents. Therefore, a significantly lower single dose of tranexamic acid can be administered over a longer time interval without reducing the plasma level of the drug to an ineffective antifibrinolytic activity level between two doses.
Tranexamic acid at a therapeutic dose Will not interfere with the coagulation process, and it will not be accompanied by any tendency to thrombosis even if it is administered for a long time.
Dosage & Administration
Adults-
Children-
Elderly patients: No reduction in dosage is necessary unless there is evidence of renal failure.
Interaction
Tranexamic Acid is a synthetic amino acid that reacts badly with penicillin-containing solutions (eg: Benzylpenicillin). Thrombolytic medicines like Streptokinase and Urokinase work against Tranexamic Acid's antifibrinolytic effect. Concurrent administration of estrogen-containing medicines, such as oral contraceptives, may increase the risk of thrombus development. During the transfusion, a direct combination of Tranexamic Acid with whole blood should be avoided.
Contraindications
Individual hypersensitivity to the product has been identified. Thromboembolic disease, arterial and venous thrombosis, endocavitary hemorrhages, and severe renal failure are all examples of thromboembolic disease.
Side Effects
Pregnancy & Lactation
Tranexamic Acid should not be used during known or suspected pregnancy because the drug's transplacental passage and potential effects on the fetus are unclear. Tranexamic Acid is excreted in breast milk at a concentration of about one-twentieth of that seen in maternal blood. In the infant, an antifibrinolytic effect is improbable.
Precautions & Warnings
Storage Conditions
Store in a dry place at 15-30°C, away from light, and keep out of children's reach.
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